Timing with Hypereutectic pistons

Hi Guys,
Looking to build a 318, the deck is currently being hot tanked and honed to .040", and milled to zero deck to suit KB167 pistons.
I'm hoping to find a set of aftermarket heads, that once cc'd, will give me a compression ration of 10.1:1
The car is 3000lbs, will be getting a 2400rpm stall and built 904 with a TF2 Transgo
The camshaft I am hoping to use is the XE268H.

My question relates to the pistons I am purchasing. They are the Keith Black 167KTM-040, reading the fitting instructions [ame]https://www.uempistons.com/installation_instructions/kb_installation.pdf[/ame]
on page 2 it states

"NOTE: Hypereutectic piston engines will require 2-4 degrees less total
ignition timing. One key to top performance is to have all cylinders
longing for the same timing numbers. Equal air flow, fuel mix, quench,
chamber temperature, swirl, and compression at each cylinder work to
this end."

Now when I dial in this camshaft, do I need an adjustable timing keyway set to degree the cam in less from what the cam card suggests? Or are they referring to the timing with the distributor?

Sorry if its a silly question

Cheers
Andrew