Some yes, some no.
Depends on each persons ability to tune. If the chart is not getting the expected results, investigation or a different approach is needed. If the chart is working as expected, then use it.
If you have a vehicle working correctly with EGR and then simply disconnect it, the fueling and timing will likely be incorrect for the situations where exhaust gas is fed back into the cylinders. Off the top of my head, part throttle acceleration and steady cruising will be off and likely need some tuning. Cold engine and wide open throttle will be uneffected.