With either the 2 barrel or what you have I would want to up my compression to at least 9.0 to 1 by either decking the block, milling the head, or a combination of the 2 and upping the exhaust system to a larger single, going with a set of Dutra duals into a larger single exhaust or possibly headers.
I will be running about 9.4 to 1 with my deck cut 90 thou, head cut 10 thou, 4 barrel Offy with a FiTech TBI and NOS Clifford long tube headers in my 65 wagon.