new rebuild startup and thermostat?

Just getting ready to fill the aluminum radiator with the evans coolant. The thought occurred to me that because this block and aluminum heads are empty of coolant, should I remove the new thermostat I installed during assembly. My concern is a lack of coolant flow and possible damage to the engine from heat. This rebuild has yet to be started. I am also trying this Evans coolant due to the aluminum heads, radiator, intake ect.