426 stroker, is it reliable?

Why sacrifice durability/longevity for a few more cubes that won't add very little power.

I'll take 3.79" crank over a 4" any day..

Yes, strokers don't "add very little power". They add a lot. Mine dyno'ed 519 hp @ 5800, 506 lb/ft @ 4100. That's with a cam that idles smooth at 900 rpm.