426 stroker, is it reliable?

Why sacrifice durability/longevity for a few more cubes that won't add very little power.

I'll take 3.79" crank over a 4" any day..
It's a matter of taking advantage of the extra cubes to find the added bennifit. While you could build a easy going stroker, I would have to say at that point it is because you want to. A well thought out 360 can perform with excellence.