426 stroker, is it reliable?

It's a matter of taking advantage of the extra cubes to find the added bennifit. While you could build a easy going stroker, I would have to say at that point it is because you want to. A well thought out 360 can perform with excellence.
I second that.
My little 367 is tons and tons of fun. As a streeter, 400 to 425 hp is screaming fun. Toning it down with a smaller cam(223@050), seemed to pick up a lot of bottom end. A 230* High-intensity /fast-rate cam makes enough power to scare yourself, so the chassis that it goes into, better be ready for it. It will need to stop, and it will need to turn,sometimes both at the same time;cuz you will get into trouble. The hope is that the chassis will save your azz.
In the beginning I wanted a stroker too. But after 16plus years, I have been content with 4.04 x 3.58 =367.136; there will be no stroker in my future.