426 stroker, is it reliable?

I will take a big bore over stroke. a B wedge with a little stroke is the best combo. geometry is longevity
And since we're talking about small blocks and stroking them....
What's a little stroke in a B? Stock stroke?
As far as a B wedge is concerned, I have a 400 in a Duster. Hoping to one day pump it up a bit. '78 is a tuff year on compression as delivered.