426 stroker, is it reliable?

Thats a great engine for a race car but the op is building a street car. Something that makes really good torque at 2500-3000 rpm is what makes a nice street engine. Not a huge cammed single plane (or tunnel rammed) engine that wont idle below 1000 rpm and needs a 4500 plus stall to work right. Not knocking ur engine at all. Just sayin you missed the point
Didn't miss any point. Over 500ft-lbs from 2800 - 3600 rpm, then it doesn't drop below 500 ft-lbs all the way through 6800. No need for a 4500 stall. 3K would do it. 3400 car, 3.91's, 3000 stall, you have a low 10 ride.

That's a nice 360 build. Is this the template you're using for your build? I'd be curious how much compression the Hughes engine had.
They used KB pistons, around 10.6cr IIRC. Iron heads more then doable for pump gas.