Front vs rear wheel sizes for best handling

Thanks for the input everyone!
Ive been thinking a bit about this after reading here. So, provided you can adjust over and understeer after choosing wheel and tire size with sway bar, shock and geometry tuning surely having different tire height and widths front and back cant directly have any negative affects on handling besides reduced braking with larger wheels. Or am I missing anything..?

In general, putting a larger tire on the rear of an A-body will make it understeer more. The only mechanically compelling reason for having a larger tire in the rear than on the front is for straight line acceleration trials.

FWIW: In addition to adjusting handling through spring rates etc., add in the variable of tire pressures (aka 3rd world chassis tuning).