Rear Gears for gas mileage

Please forgive me for the stupid question that I'm about to ask. I hear people talk about gear ratios all the time, I hear numbers like 331s, 355s and 373s and a bunch more. So here is my question, what is the difference ?
If both rear wheels spun in the same direction, 3.55:1.
Thank you Mr Gorsky. I did make sure both wheels turned in the same direction before doing the count.