Cam, Compression ratio and octane ratings??? Help?!

I know this is a potential Pandora's Box, but what's the deal with so many people saying that you cant run 10:1 compression, stock iron heads, and a "mild" cam on pump gas?!

My confusion is, stock early 273HP and 340HP came from the factory rated at 10.5:1cr, with iron heads and what was a "mild" performance cam. So were those cars unable to run without knocking on 93 octane fuel? I'm aware that much higher grades of gas were more readily available in the '60s, but was that an absolute requirement?

I'm almost ready to put my very mild 360 back together, and in the process of asking for cam advice, have developed a concern. The goal of the build was to make a warmed over copy of a stock 340HP, just with a 360 bottom end. The engine is essentially a .060" over 360, with hypereutectic pistons 0.010" below deck, stock 587 heads with 1.88/1.60 valves. Eddy LD340 intake. 750cfm carb. Stock 340HP exh manifolds. Dual 2.5" exhaust.

Having not CCd the heads, I did my math using an assumed 73cc chamber, and ended up with roughly 9.8:1cr.

The cam I was about locked in on was the Comp 268AH-10, which is just slightly hotter than a stock 340/360 4bbl cam, (with exception to the '68 4spd cam).

Specs on said cam are as follows:

Duration 268 intake 276 exhaust
@0.050" 222 intake 226 exhaust
Valve lift 0.464" int 0.464 exh
LSA 110deg
Centerline 106deg

This is the cam Id like to run, as this engine is going in my daily driver and am looking for great manners, but a little extra muscle. I'm not shooting for max power obviously! Just a reliable healthy 360.

Oh, and just so its out there, I have absolutely no qualms about having to run 93octane gasoline!