Anyone using stock ECM and harness?

Do you plan to 'tune' the ECM?
Here is what I'm curious about. I know the ECM can be tuned/reprogrammed/flashed, whatever you want to call it, to not look for an input from the immobilizer. Can this be done for other modules? Will the ECM allow the engine to run, outside of 'limp mode', without an ABS input? Can the ECM's ABS input be shut off with a tuner?

Hotwire reprogrammed my ECU.