Electrical gremlins

Yeah that's about the 2nd worst possible place to put a fuse. But blowing a fuse there should not shut the vehicle down.Since it at least seems to prevent a restart,( whether cranking or firing or fueling you haven't told us yet), I think it's time to revisit the wiring diagram.
Unless the battery is very low or dead,and it's a no crank situation; which still does not involve that fuse as to starting.....
But, I might speculate;
If the battery is low to start with, then the alternator could go into overdrive right after a successful start, and if the fuse is unable to pass the juice, it will pop. And if you are not watching the voltmeter, you may not catch the popping until you return to home.
Since the alternator output is somewhat dependent on engine rpm, it might not pop the fuse until 30 plus mph, depending on your driving style.