General AFR Guidance (Holley Tuning)

Is there a rule of thumb for optimal AFR for making power? Is it 14.7 throughout (idle, tip-in, cruise, WOT, etc)?

In the past I've tuned idle mixture based on the highest vacuum reading, but was unsure where the optimal AFR was for cruise and WOT. I finally got my wideband installed, so I'm all ears. The carbs I'm dealing with are a 670 Holley street avenger and Holley 4779 750dp.

Thanks!