If dear old Dad puts it in Drive, and the engine never gets past 3500/4000..........I don't get the big cam idea. And if you stuff a smaller cam in there then you will get into DCr issues. Sooooo, why worry about walking the thin line? I'm a little late to the party, but I'd have to agree with post#27, as to milling the pistons to set the quench, AFTER the Cr has been established, to work with the application specific cam. If the cams ICA calls for a chamber size that can be achieved with a gasket thickness, that simultaneously hits the squish zone then Ba-da-boom you are done. Conversely, if you select a gasket thickness that hits the squish target and then determine the Scr to be compatible with such and such a cam with an appropriate ICA, again you are golden. If that cam then is suitable for dear old Dad ,then you are Triple-Golden.
FWI; I have been running about .033 for around 100,000 miles, withKB107s, Eddies,factory 340 rods,and shifting stick at around 7000. Yeah it's been higher,often, and a lot higher.