I'd run the 4.30s. The heads will either need some work (spring seats, guides cut down, matched springs, better retainers and locks) or outright replacement. Cheapie headers are all that's needed. A dual plane intake, a carb at least 750cfm, a cam with some lift and duration, and you'll have what you need if the suspension has a few new parts and is setup right. Something like that should go mid 12s pretty easilly.
