I don't know you or your bride but I sense that an intervention is needed with professionals to show her how to change her daily routine. A hospital rehab center or something similar where they help her through each day with proper diet, exercise, instruction and compassion until she can see how it can help her. Beating back debilitating pain and the depression it can cause needs skilled help. Please press her doc for more direction and help in this matter or call the local medical society for help. You both need OUTSIDE help. Don't be afraid to ask for help. Don't fight this alone.....