combustion chamber question

Keep it around .040 if you're wanting to run higher rpms often. Rod stretch, heat expansion, wrist pin wear, and bearing wear is a thing and can further tighten the quench. A stroker already has faster piston speeds. With forged and strengthened internals, this is not as much an issue.

Quench is only one piece to a top running engine that will last and never detonate. Proper air/fuel tuning, smooth timing, consistent valve timing/lift from cylinder to cylinder, proper fuel, etc all play a role.