1994 dodge Dakota 318 into duster, will it work?

What is a Scotty?
The 318 will be neutral balance. Traditional LA engine pullies work. The water pump may be reverse rotation if the engine had a serpentine belt. If the engine is a "Magnum" series, the threaded bolt holes in the heads may be in different places than a traditional 1967-02 318. This makes for some interesting fitment issues for alternator brackets, P/S brackets, etc.The exhaust manifold on the right/2468 side fits and is a good unit. You'll need a different LH manifold as the outlet shares the same space as the steering shaft.
As said, you'll need a center sump oil pan and pickup.
If using headers, there are casting nubs just below the cylinder deck that interfere. They need to be cut or ground off for the pipes to fit and the header flange to sit flush to the heads.