1994 dodge Dakota 318 into duster, will it work?

This is an up grade, not a down grade.

How's the 440 mounted? Biscuit mounts, spool mounts, elephant ears?

The trans requires reworking the tunnel, as mentioned, or using a 727/904.

The drive shaft gotta get modified.

Pick your fuelling method and exhaust method, then use "search"; those are covered extensively already.