Use or don't use vacuum advance on distributor???????????????????

Only reason I said it didn't matter initially was because I was trying to keep it about the distributer and how to get the distributer to work with manifold vacuum. I was trying to keep it on point. No matter my set up and whether I am running a slant six with a one barrel or a 440 with dual quads I was trying to ask how to tune a motor any motor to manifold vacuum. I know I have issues with the carb but I didn't want to high jack a distributer thread with carb questions.
OK, you tune the engine to work with the vacuum advance connected. You don't "get" the distributor to work with manifold vacuum, it already will.