3.8 #1 misfire on my grand caravan

I've replaced the plugs at least 3xs since this started and I've replaced the wires once it twice. All this last year maybe less time.
I think this started after it seemed to have tranny issues. When going up the mountains on the big hills when I was in third and it hit 3k rpm it would jump to redline and not shift. Was saying I put and output sensors. Replaced those a few times along with tranny fluid and filter. Finally found out the cat was clogged so I hollowed it out and then this misfire began.