3.8 #1 misfire on my grand caravan

These years of vans have a wiring harness that droops towards the exhaust manifold in the back of the engine over time. They have been known to melt and cause problems. Something to check into. I tied mine up with a stupid zip tie. I'm at 200k, and my brother is over 250k. We both have 3.3's, but they are basically the same engines externally. He has only replaced the water pump, and mine.... nothing

The 3.3 and 3.8 are the same engine except for bore and stroke... All parts on both engines are the same except for fuel injectors and throttle body are different from 3.3 L to 3.8 L.

The 3.8 used to have an aluminum upper intake manifold, but they changed it to the plastic 3.8 L intake after a couple of years for cost reduction...