Red locktite on freeze plugs?

Yep. Drain the block completely by removing the block drains. I had a friend crack a block because he thought pulling the lower hose off would be sufficient.
Truth be told you could probably use brass plugs dry and have no leaks for the life of the motor. I did however, right, wrong, or indifferent use red loctite and I haven't had any problems. I would inspect each core plug hole for rust and pitting. I cleaned mine up with emery cloth. Then installed the brass plugs with the red loctite. Good times...God bless America!!!!