somethings not right here

So if I test my coolant mix and its boil over is 260. Anything below that is a safe temp? So running at 250 in this case is safe?
Next scenario is straight water, same thing but boil over is NOW 212.
Your boil point can vary quite a bit.
Then like you said pressurizing it raises it even more.
Safe operating temp is the last degree before it boils over.

Did a 350 in a vette this spring,230 before fans ran. Factory setting. Cooling system pressure raises boiling point also.