Help please

I have a 1984 225 slant 6, I just put brand new plugs and wires and everything on it and recently it started acting real Goofy, when I'm driving it down the road I step on the accelerator pedal and I hear an awful wine like a vacuum leak or something but it's not a sucking air sound as more of a whistle but it lets up when I let off the accelerator and it won't do it when I'm just sitting still at an idle it seems like the motor has to be under a load,... I'm freaking out and I need help

Check your carb and make sure all the screws that hold the sections together are tight, and that the base is tight on the intake.
The whistle sound is sometimes a gasket getting air past it.