A (forged) 340 Crank is Not a (forged) 273/318 Crank?

dibbons said

I wonder how many have switched cranks between 340 and 273/318 without taking into consideration those holes? What is the worst that could happen?

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I've used 273 cranks (great with aluminum rods...less balance work), 318, 318 poly and 340 cranks. I always drilled the 1 and 4 rod throws. Once balanced, they don't know from whence they came.