650cfm QFT Carb Tuning / 383 / 727

Green cam is generally about the most early lift a 4150 needs. If it really needs the blue, so be it, but I would encourage testing different nozzles with the green before settling on the blue.
Nothing wrong with experimenting with the secondaries disconnected to isolate the primaries. There is a slight disadvantage in that airflow and fuel distribution it's not going to be quite the same as when all four throttles are open. But its a useful tuning and learning technique.