Acting like one cylinder firing lean.

No I mean put a scanner on your OBD EFI daily driver, and watch what it does.
Most Mopar streeters benefit from a well tuned VA system. About the biggest can you can find or build is 22*. So by the time the the rpm rises to stall speed around 1850 on a stocker, he mechanical timing could be 20/25 degrees and so the VA will add it's load of say 20 to that, and the engine will be very happy with 40/45. But as soon as you increase the load by stepping on the gas, the VA starts dropping timing, and by WOT or sooner it has all dropped out. The VA is an automatic timing control, and once tuned you never have to think about it again. The extra advance it brings to the party, allows you to really lean the low speed circuit out, saving you many many gallons of gas over the lifetime of the engine. They say lean is mean, but the only time I agree with that is at part throttle. Your engine will really get snappy, and happy, with a well worked out VA and lean AFR combo.
I agree with BigBlock as to the use of an IR gun; it will tell you a lot. Hunt for the hottest spot in a straight section of pipe within about 2 inches of the head; corners tend to run hotter. A normal idle temp might be around 350/450
AJ I agree with you that a well tuned vacuum advance can be benifical, if you have vacuum at idle. Lumpy cams produce little or no vacuum at idle. I have had several hi performance engines that I ran no VA because the engine had little or no vacuum.