Lets talk small block stroker cranks

As far as i am aware they come in the following flavors( generally available)
3.79
4.0
4.125
4.250

I used to be a big believer in the more inches the better. I know Ron Silva creatlvely came up with a 501 inch monster a few years back.
But in more recent times i think the 3.79 crank and if possible a big bore make the most effective combination, up to and including W8 heads.
The fact is most of these long arms create more inches than the majority of available heads can handle.
I have only run W5 heads thus far as the best i have used, and even they are marginal with a 4 inch crank.
They also start to get a diminishing return regards side loading, rod ratio and other things with the longer arms. You kinda get to the point do you want to drag race or sit on a tractor and plow a field.
Has anybody on here used 4.125/ 4.250 stuff, how did you like it? Race or street
Curious what the gurus on here( builders) think.