We need to remember what these heads were designed for. The W-2 was designed for 330-340 inch engines, that were significantly induction limited. The W-5 head was an improvement on the W-2 and that's about all of that.
Best single 4 being the INDY and the tunnel ram dual quads. Unless you know of a manufacturer of a IR set up....
I've said before that a W-2 based engine, with today's cam and valve train with a reasonable RPM of say 7500 shift speed, with a well prepped head can only truly support 360, maybe 370 inches at that RPM.
With well prepped W-5 heads and the same configuration, my opinion is 385 inches or so is about all you can feed, relatively well.
That’s how I see it at a max. I pondered the worth of the new Victor head on these displacements.
These displacements & heads still make a good package, street or strip. But only so quick they can run.
One last thought...if you use a 3.58 or even a 3.79 stroke crank I'd stick the longest rod in it I could. I'd rather use a 3.58 stroke and a 6.25 rod than be stuck with a 6.125 rod and a 3.79 stroke. When you become induction limited, rod ratio becomes more important.