What kind of Gen III engine would you build around this Cam?

i dont know the lobe numbers on that cam there. however i also dont know what heads and pistons you have in your engine. the pre 09 5.7 heads wont allow more than 550 lift without crashing into the valve guide i believe. the stock pre09 5.7 also wont clear big lift cams like that either.

those 2 things mentioned otherwise that cam is about perfect or a touch on the rowdy side. be 7k rpms or so.

id go to a 6.1 head, thicker head gaskets to drop the compression back down best you can. you maybe ok with the pistons but the power the pistons suck anyways and will give up the ghost in short power added to them.
try some drop in rods n pistons and get eagle heads to match and you got a badass combo with a blower. 6-700hp easily