First time down the track

67Cuda408 said

10:1 compression
Forged KB pistons
Ported Cast Iron heads 2.02/1.60 valves flowed at 280cfm average between all runners
.510 .510 cam 244/244 at .50
Edelbrock RPM Air Gap with Holley 750 port matched to the intake, not gasket matched
Headers
All MSD ignition
20* initial timing
40* total timing

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Start with bringing the timing back to 32-34 (that is where my 410 stroker was happiest)....there are more than likely more issues, but it is a start. My guess is the heads don't flow anywhere near what you were told. That is a pretty unrealistic number from a stock head.

Things I would check:

Have you messed with the carb jetting yet? (Keep jetting up for best MPH, when it slows down back it up and you're set.)
What fuel pump?
Might want to do a leak down test.

For what its worth, my 410 stroker was 10.8:1 compression, a little bigger cam, heads that flowed 293 in a 3200# 67 Barracuda...it ran mid 10's, but would still do high 11's when I lifted a little before half track and coasted all the way through the 1/4 mile....something is DEFINITELY wrong big time.