Back in the 70's I bought used steel horse/stock trailers and had them sandblasted and painted them with what is know n as alkyd enamel, NO hardner. Painting outside. Then I got some acrylic enamel added hardner and painted a trailer with it.. It did not hit me till 24 hrs later. It felt like I was running a high fever, but I was not. Really knocked the **** out of me.
I still paint but should not. But at age 70 something will kill me right? I use the good 3m respirators for organic vapors. BUT as stated before the only real safeguard is a fresh air system !!!!!!!! The stuff will also be absorbed thru your eye.
Some people paint and has no "observe" effect. Some people die. Pro s use a paint booth for a reason. Downdraft pulls away a lot of the vapors. Not just because it keeps the dust out of your paint!
I am not trying to be an alarmist. Just be aware. And Round Up, read up on it.