Comp cams xe268h for 318

I know I'm not in risk or anything but if I were to build another engine say 10:1 scr and get in or about that 8dcr how do avoid detonation? Is is simply a change in fuel? Or can you do something to the combo timing jetting advance retard etc?
Most all of the things you mention will effect how close you come to detonation:
Other things: