wheel screws hole in wheels

Hello 68fsh.
If you are referring to the screws that are installed to help keep the tire from slipping on the rim under hard acceleration yes you can run the rims without the screws with some exceptions.
How big are the holes?
Where in the bead area are the holes?
If the holes (screws) are like depicted in this picture you should be ok.
Most street tires have good thick beads that will seal the holes and not leak air (or nitrogen).
P/S you can also cut the screws down flush with the inside of the bead (no sharp edge) so the screw heads are still on the outside thus no ugly holes. All depends on the look you want.
If you do this locktite them in them cut them off.
Hope this helps.
happy Mopar :)
Arron
Rim with screws.jpg