does locktite go bad?

Which 351? Are you sure the bolts are not bottoming out? Are the holes blind or open to coolant? If they are open to coolant then you may need to use a gasket maker on the threads. Read up on the type of Loctite you are using, they set up in different ways like in absence of oxygen, in atmosphere or with an activator. I had to redo my 460 (Yes I have a Ford and Drive a Subaru to work, both blue ovals).
The Windsor in my 87 bronco (plowtruck)
I verified the bolts did not bottom out without washers, so there is NO was they bottom out with them
These are blind holes, no coolant getting to them, but there may be trace amounts of "the right stuff" from when i was still trying to get a paper gasket to seal (long story, it has an O ring gasket now)