Jets and Power Valves 750 Holley 4150

Mostly that would be on engines that are inefficient at part throttle.

Seems reasonable.
The situation where it gets people in trouble is engines with very poor idle characteristics. An engine that idles with 5 "Hg, very well might need a PV that opens at 6 or 8"Hg or there will be a flat spot in part throttle acceleration.
You are probably right, I just haven't tuned any that big. The biggest I have tuned is the Mopar 292/292/108. At 11.3Scr, it was fairly easy. On that combo,I did quite a bit of experimenting. I tried 4 different carbs and 3 different intakes, and 3 different Ica's. It kept me busy for awhile. I finally cut a hole in the hood and gave her some fresh air.In the end it didn't fit my combo and driving style, so I pulled and sold it. Great cam! at WOT. Not so good in a streeter with a stick and 3.55s. She wanted a lot more rear gear and an overdrive. Smaller cam was waaay cheaper