Today’s ethanol gas in carburetors

How detrimental with today’s ethanol gasoline be to a Thermo quad or Edelbrock carburetor if you had to drive several one thousand mile trips totaling four to 10,000 miles?

How long would it be before you would need a rebuild or have detrimental problems with the carburetors functioning ?

They sell those little blue bottles of ethanol catalyst that supposed to neutralize and diminish any problems -Is that a worthy the solution?