Yes, but because Greyhound only cares about length and weight you can duct tape or zip tie 2 or 3 tires together...maybe even 4 tires together depending on tire width. You actually get a better deal shipping 2 or 3 tires together because that way it's only considered one item. That way they don't get separated. I've shipped tons of car stuff through Greyhound (frame rails, some tall bucket seats, fenders, etc). It all arrived on time within a day or two. treblig