!!!!!CALLING CAM EXPERTS!!!!!

I have read what David Vizard has to say about cam design, and it impresses me. Vizard has decades of testing ,head porting and engine building under his belt, including some Indy car and foriegn motors.
Basically lobe seperation is a function of overlap breathing, and how many cubes that flow has to feed. A god set of heads on a 383 might like a 112 or 110 lsa, but the same heads bolted to a 512 stroker might want something as tight as 104! All those extra cubes desperately need the extra time to get airflow moving. There is five times more vacuum trying to get air moving thanks to well tuned headers than at ANY OTHER time in the induction cycle. Thats why the correct lsa is so important. Lots going on!
So far, overlap duration discussed is based on a single pattern cam. The duration on intake and exhaust lobes will dictate the rpm. Go to a dual pattern cam and for every four degrees extra exhaust duration, you have to spread the lsa 1 degree to keep the same overlap duration.