Well, one would hope that the bolt holes and center hole were produced to some kind of tight tolerance during manufacturing, on both the axles and on the wheels. Actually, I've seen how modern aluminum wheels are machined. The lathe that turns them has the lug hole drilling tool in it. While the wheel is still chucked in the turning jaws/fixture, the lug holes are put in. True-position of those lug holes is probably so close you don't even need to bother measuring it. You have probably a dozen or so things that will add up to a huge tolerance stack if you want to start worrying about them. Like, what's the runout of those wheel bearings? Or the tire runout or roundness?
