I think when most people envision a big block, they think of something like a 460 Ford, which will suck a gas station dry just by driving past it.
20 years ago, I had a '65 New Yorker for a short time and it surprised me how easy it was on gas. I was big into GM stuff at the time but I had a buddy who was a long-time Mopar guy, and he told me the Chryslers were always more efficient than Ford or Chevy because the engines were a more efficient design. After learning more about Mopar engines, I tend to believe him.