Realistic valvetrain expectations.

A good carb can hang with EFI on a dyno, for a given build. That's it. Where EFI leaves it in the dust all day, everyday, is living with the thing and designing the build. Dry ports are huge difference. Spot on mixture, all the time, huge difference.

Modern engines have tiny ring packages=low friction. I'me already sorta building the engine you're planning (6.800 rods, 3.380 stroke), and I can turn the engine over to set lash with my bare hands on the crank pulley, without blowing a gut.

Dry intakes mean huge ports and massive airflow without worry about vacuum signal and mixture fallout. I would spend a little more and get a Victor or TF single plane plumbed for direct port EFI and use the 270 TF's. Dry intake. More stroke would make sense too, but your build. 12.5:1 on E85 would be nice too. S/F....Ken M