Holley/Demon Carb stumble

I had the same issues a while back... I had a 950 ProForm that uses the same venture size as the 850. I juggled shooter's, shooters with tubes, cams, and even a 50cc in the rear.
I finally went with a 750 HP I modified. I'm happy now, and I'd rather take a ball peen hammer to the forehead, than do that again !!
our motors are different.. mines a 360, yours a 408, so not a direct comparo, but nevertheless.

How much Ignition lead/total timing are you using? Open spacer, or 4 hole? Cam in the 240s @ .050 ?

I agree. you need to check timing first.
then consider temperature. It will stumble if the engine is cold.
Go back to the stock squirter for now. consider rebuilding the carb. best to know what you have.
Also I had 2 new power valves be defective.took a while to sort.
So, if you have the timing set, engine warmed up,carb gone through, then consider trying different carb tricks.