To Vacuum Advance or Not to Vacuum Advance

Ok, getting close to completing my engine swap - final pieces

What are the pros/cons to run vacuum advance on a performance engine

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Adding more timing at part throttle will reduce exhaust temp by a bunch and you'll improve fuel economy. You said you didn't care about gas mileage but I bet you care about excess fuel washing down your cylinder walls. You might also care about a 300 or 400 degree difference in exhaust gas temp.