well, I am going through this right now. Old motor - had eddy performer and later a thunder series carb. Super easy to tune - vacuum gauge and flat head. Of course there isnt much else you could do. You can play with the jets and metering rods
I now have a holly 4160
And this how I feel. I started researching and everything is all "super" tuning and super advanced tricks. I will figure this out and get it tuned, because I want the extra throttle response and other benefits of the holly.