225 slant 6

While nobody can dispute the significant differences between the aluminum block and the iron block, none of them bears on the bottom-end beefiness of the engine. The skirt depth is the same: adequate in aluminum, way more than adequate in iron—for one example.
Dan, I'm not disputing what you said, but just adding an observation, and asking a question. The big blocks had a very similar skirt design, and had no thought of being made of aluminum. Also the aluminum and iron slant blocks had a totally different main bearing support.
Also, if as was stated, that one of the reasons for making an aluminum engine was to save money on machining, why not save money by taking metal out of the iron block