MSD or not

That one is for a small block.
Really depends what your goals are, if your dealing with stock or modified engine, and where and how you will be using the car.
Reliability? Like just about everything aftermarket.
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Jegg’s has a big block version for like 150 bucks full kit ready to install. I installed one on my buddies 383 dart with no problems. There are many ways to achieve this ignition task. Choice your poison and have fun tuning it to perform, then let it rip potato chip.